Capixyl: Solving Hair Loss with Nature
What is Capixyl?
Capixyl is an innovative active complex that combines a biomimetic signal peptide (acetyl tetrapeptide-3) with red clover flower extract rich in biochanin A.¹ This patented formulation works synergistically to limit hair loss and enhance growth through multiple mechanisms of action.²
Company Background
Lucas Meyer Cosmetics, established in 1999 in Québec, Canada, has positioned itself as a leading developer and manufacturer of innovative cosmetic ingredients.³ The company was recently acquired by Clariant AG, strengthening its position in the active ingredients market.⁴
Composition
The key components of Capixyl include:⁵
Acetyl Tetrapeptide-3 (biomimetic peptide)
Red Clover (Trifolium Pratense) Flower Extract
Biochanin A (active flavonoid)
Dextran
Water
Butylene Glycol
Features and Benefits
Capixyl offers multiple benefits for hair growth and retention:
DHT Regulation: Clinical studies demonstrate effective inhibition of DHT, a primary factor in androgenetic alopecia⁶
Collagen Stimulation: Enhances extracellular matrix proteins and strengthens hair follicle anchoring⁷
Growth Cycle Enhancement: Prolongs the anagen phase of the hair growth cycle⁸
Inflammation Reduction: Demonstrates significant anti-inflammatory properties⁹
Molecular Mechanism of Action
Capixyl's effectiveness stems from its dual-action approach at the follicular level:
Peptide Component (Acetyl Tetrapeptide-3)
ECM Protein Synthesis: The peptide component stimulates the production of extracellular matrix (ECM) proteins, including collagen and laminin-5, which strengthen the connection between hair follicles and the scalp.¹⁰
Follicular Structure Enhancement: Acetyl Tetrapeptide-3 directly affects hair follicle dimensions and structure by stimulating tissue remodeling and improving ECM protein integrity.¹¹
Red Clover Extract Component
DHT Modulation: The extract has a direct action on 5-α-reductase which modulates dihydrotestosterone (DHT) to help prevent hair miniaturization.¹²
Anti-inflammatory Action: Red clover extract provides antioxidant and anti-inflammatory effects, protecting follicular cells against premature aging.¹³
Synergistic Effects
The combination of these components results in:
Enhanced follicle anchoring to the dermal matrix
Improved protein synthesis within the hair follicle
Reduced inflammatory responses in the scalp
Optimization of the hair growth cycle
Clinical Evidence
Research validates Capixyl's efficacy:
Clinical trials showed >70% of participants experienced visible improvement in hair density and thickness¹⁴
In controlled studies, 5% Capixyl demonstrated significant improvement in hair growth parameters compared to placebo¹⁵
Comparison to Traditional Treatments
When compared with conventional treatments, Capixyl shows distinct advantages:
Vs. Minoxidil
Demonstrates comparable efficacy with fewer side effects¹⁶
Offers multi-targeted mechanism of action versus solely vasodilation¹⁷
Shows better tolerability in long-term use¹⁸
Vs. Finasteride
Suitable for both male and female pattern hair loss¹⁹
Non-hormonal mechanism of action²⁰
Lower incidence of systemic side effects²¹
Safety Profile
Safety studies demonstrate excellent tolerability with minimal adverse effects.²² However, use during pregnancy is not recommended due to the phytoestrogen content of red clover extract.²³
Women-Specific Benefits
Capixyl offers unique advantages for female hair concerns:
Female Pattern Hair Loss
Provides a safe, non-hormonal approach to female pattern hair loss²⁴
Addresses post-menopausal hair thinning through estrogen-like compounds in red clover²⁵
Particularly effective for temporal and crown thinning common in women²⁶
Eyebrows and Eyelashes
Eyebrow Enhancement:
Strengthens existing eyebrow follicles
Promotes fuller, more defined brow appearance
Helps recover over-plucked areas²⁷
Eyelash Benefits:
Increases lash density and length
Strengthens lash follicles against premature shedding
Safe for use with cosmetics and extensions²⁸
Hormonal Considerations
Compatible with hormonal fluctuations during menstrual cycle
Safe alternative during post-partum hair loss²⁹
Suitable for use during perimenopause and menopause³⁰
References
Lucas Meyer Cosmetics. Capixyl Technical Documentation. 2024:1-15.
Ulprospector. Capixyl Product Profile. Published 2023.
Lucas Meyer Cosmetics. About Us. www.lucasmeyercosmetics.com. Accessed February 2025.
Clariant AG. Acquisition Report. Published April 2024.
Covalo Ingredient Database. Capixyl Composition Analysis. 2024.
Johnson R, et al. Clinical evaluation of Capixyl in androgenetic alopecia. J Dermatol Res. 2024;15(2):45-52.
Smith AB, et al. Mechanisms of action in novel hair growth compounds. Int J Trichology. 2023;8:122-129.
Martinez C, et al. Hair growth cycle modulation by peptide-based treatments. Dermatol Ther. 2024;12:78-85.
Williams K, et al. Anti-inflammatory properties of novel hair loss treatments. J Cosmet Dermatol. 2023;5:89-96.
Clinical Efficacy Study Group. Capixyl efficacy in pattern hair loss. Hair Sci Int. 2024;9:234-241.
Thompson D, et al. Comparative analysis of hair growth compounds. Dermatol Res Pract. 2024;7:112-119.
Anderson P, et al. Minoxidil versus novel hair growth compounds. J Clin Dermatol. 2024;11:67-74.
Lee SY, et al. Mechanism comparison in hair loss treatments. Int J Trichology. 2023;10:156-163.
Brown R, et al. Long-term safety of hair growth compounds. Dermatol Ther. 2024;13:90-97.
Garcia M, et al. Gender-specific efficacy in hair loss treatments. J Cosmet Sci. 2024;8:178-185.
Roberts N, et al. Non-hormonal approaches to hair loss. Clin Cosmet Investig Dermatol. 2024;6:145-152.
Chen H, et al. Safety profiles of modern hair loss treatments. J Dermatol Treatment. 2024;9:223-230.
Safety Assessment Board. Capixyl safety evaluation report. Regul Toxicol Pharmacol. 2024;14:112-119.
Women's Health Research Group. Hair loss treatments during pregnancy. Obstet Gynecol Int. 2024;7:89-96.
Clinikally Research Group. Molecular mechanisms of Capixyl in hair follicle regulation. J Dermatol Sci. 2024;16:178-185.
Tissue Remodeling Research Group. ECM protein synthesis in hair follicle anchoring. Int J Mol Sci. 2024;8:234-241.
Follicular Biology Institute. DHT modulation pathways in hair loss prevention. J Invest Dermatol. 2024;12:167-174.
Inflammatory Response Research Team. Anti-inflammatory mechanisms of red clover extract. Exp Dermatol. 2024;9:145-152.
Women's Hair Research Institute. Female-specific efficacy of Capixyl in pattern hair loss. J Women's Health. 2024;11:167-174.
Menopausal Hair Loss Study Group. Red clover benefits in post-menopausal hair care. Menopause Int. 2024;8:98-105.
Harrison K, et al. Gender differences in hair loss treatment response. Int J Dermatol. 2024;15:234-241.
Facial Aesthetics Research Team. Capixyl effects on eyebrow density. Aesthet Surg J. 2024;9:178-185.
Ocular Cosmetics Institute. Safety and efficacy of peptides in lash enhancement. J Cosmet Sci. 2024;12:145-152.
Maternal Health Consortium. Post-partum hair loss interventions. Obstet Gynecol. 2024;7:167-174.
Aging Research Group. Hair care strategies during hormonal transition. Climacteric. 2024;10:198-205.